Born in 1942 in Chicago, Goldyne began drawing during his childhood because ill health prevented him from participating in sports. He majored in art history at the University of California at Berkeley, but fearing that he would be unable to make a living as an artist, he went on to earn his M.D. at the University of California School of Medicine in San Francisco. Art won out in the end; after completing his medical studies, Goldyne studied at Harvard, earning an M..A. in fine arts in 1970. Before attending Harvard, in 1968 he had made his first prints in black-and-white at the Impressions Workshop in Cambridge, Massachusetts. After seeing the catalogue for an exhibition of Degas monotypes, Goldyne began to produce monotypes and lithographs. Returning to San Francisco after completing his studies at Harvard, he continued to print at the studio of Jeanne Gantz in Berkeley. In 1973 his first solo exhibition of prints was presented at the Quay Gallery in San Francisco. An immediate success, the show helped to bring monotypes to the public¹s attention. In 1976 Goldyne produced a series of monotype books,and in 1985 he undertook a monumental book project titled Het Achterhuis/Anne Frank: Diary of a Young Girl. It was shown in 1986 at the Jewish Community Museum in San Francisco.